CompletedNot Applicable

Electrical Resynchronization and Acute Hemodynamic Effects of Direct His Bundle Pacing Compared to Biventricular Pacing

Switzerland19 participantsStarted 2019-04-01

Plain-language summary

The aims are to compare Direct His Bundle Pacing (DHBP) with biventricular pacing (BiV) in terms of electrical resynchronization using electrocardiographic imaging (ECGI) and also in terms of acute hemodynamical effect using finger plethysmography and conduction velocimetry. The study will be a randomized crossover design with acute measurements.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Treatment of heart failure with a standard indication for CRT (NYHA III-IV, LVEF \< 35% and QRS \> 130ms; or LVEF\< 40% and requirement for frequent ventricular pacing, irrespective of baseline QRS duration) and optimal medical treatment. * Permanent atrial fibrillation (allowing connection of the DHBP lead to the atrial port). * Patients implanted with 1) a CRT pacemaker or CRT defibrillator 2) a His lead with selective or non-selective DHBP, connected to the atrial port of the generator 3) a functional right ventricular lead and 4) a functional coronary sinus lead. * DHBP with selective or non-selective His capture Exclusion Criteria: * Age \<18 years * Pregnancy * Inability to undergo CT or an MRI (e.g. due to severe claustrophobia) * Inability or refusal to sign the patient informed consent form.

What they're measuring

Left ventricular activation time

Timeframe: 5 minutes

Trial details

NCT IDNCT03452462

SponsorUniversity Hospital, Geneva

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-08-30

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