CompletedPhase 4

Different Effects of Non-calcium Phosphate Binders on Serum Calcium

Poland34 participantsStarted 2018-03-01

Plain-language summary

Sevelamer hydrochloride (SE) can increase intestinal calcium absorption in contrast to lanthanum carbonate (LA). Study compared effect of LA and SE on serum and urine phosphate and calcium, and hormones regulating mineral-bone metabolism.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult patient * with eGFR ≤45 ml/min Exclusion Criteria: * hypercalcemia (\>ULN), * serum phosphate \>1.2 times normal value * calcium-phosphate disturbances not associated with CKD, e.g. Paget disease, osteoporosis, any bone fracture within 6 months before study, multiple myeloma or any neoplastic disease, liver or biliary tract disease, primary hyperparathyroidism

What they're measuring

the change of serum calcium for 24 hours after each drug

Timeframe: 3, 6, 12 and 24 hours after administration of each drug

Trial details

NCT IDNCT03451019

SponsorMedical University of Lodz

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-15

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