Neurofeedback Training for High Risk Psychosis (NCT03447548) | Clinical Trial Compass
CompletedNot Applicable
Neurofeedback Training for High Risk Psychosis
United States81 participantsStarted 2018-03-01
Plain-language summary
Young people who are at great risk for developing psychosis have cognitive deficits which are strongly related to functioning in the community. This study looks to target a specific cognitive skill called processing speed to see if improving the ability to process information in a timely manner will improve social function in adolescents and young adults at risk for developing schizophrenia. Half will receive neurofeedback cognitive training targeting processing speed while the other half will receive an active control.
Who can participate
Age range12 Years – 25 Years
SexALL
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Inclusion Criteria:
* Case identification and ascertainment depends on the fulfillment of the Criteria of Prodromal States as evaluated using the Structured Interview for Prodromal Syndromes: (1) attenuated positive symptom state which includes the emergence or worsening over the past year of non-psychotic disturbances in thought content, thought process or perceptual abnormality, (2) brief intermittent positive symptoms, and (3) genetic risk and deterioration.
* Processing speed at least 0.5 Standard Deviation below the norm, as indexed by baseline performance on Digit Symbol Coding of 8 or below
* Age range 12-25 (this age range also comprises the main period of risk for psychosis)
* Written informed consent by patients \>18 years old, and written assent by subjects \<18 years old, with written informed consent by both parents (unless one is deceased or unavailable). Participants who turn 18 while in the study will be re-consented as adults through written informed consent.
Exclusion Criteria:
* Current or past diagnosis of psychotic disorder noted at baseline assessment (schizophrenia, schizophreniform, bipolar, schizoaffective, major depression with psychotic features, substance-induced psychosis, psychosis due to a medical condition.
* Neurological, neuroendocrine or major medical disorders: as putative prodromal symptoms could be secondary to these and unrelated to risk for primary psychotic disorders (clinical interview), including seizure disorder and history of si…
What they're measuring
1
Change on the Wechsler Intelligence Scale Processing Speed Index