Can we Transfuse Blood Over Shorter Period ?

Inclusion Criteria: * Any condition that expected to receive more than one blood transfusion, like thalassemia major or intermedia, sickle cell anemia, aplastic anemia, malignant diseases. * Age range of 3.0-14 years, inclusive, at the time of study entry. * Parent or guardian willing and able to provide informed consent. * Ability to comply with study-related treatments, evaluations, and follow-up. * Normal Echo study that had been done in the last year. Exclusion Criteria: * Inability to receive or tolerate chronic red blood cell (RBC) transfusion therapy, due to any of the following: * Multiple RBC alloantibodies making cross-matching difficult or impossible. * RBC autoantibodies making cross-matching difficult or impossible. * Life threatening condition like shock. * Hemodynamically unstable. * Hypoxia with oxygen saturation less than 92% on room air. * Any patient with signs of respiratory distress (using accessory muscle or acting ala nasi). * Fluid balance more than 1 liter. * Known severe allergy (anaphylaxis) to blood transfusion. * Previous history of Transfusion associated circulatory overload (TACO). * Heart failure or poor ejection fraction less than 60%. * Current use of therapeutic agents for heart failure or arrhythmia. * Newly diagnosed with active cancers in the 1st week of induction therapy. * Severe anemia- Hb \<6gm/dl at the day of transfusion. * Serum creatinine more than twice the upper limit for age.