UnknownNot Applicable

Mechanisms of Alcohol Sensitivity in AERD

United States60 participantsStarted 2018-05-01

Plain-language summary

The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen with red wine.

Who can participate

Age range21 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy Controls - must be 21 years or older * Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages Exclusion Criteria: * Enzymopathies * Mastocytosis * Alcoholism * Prior severe respiratory reaction to alcohol consumption * Current pregnancy * Monoamine Oxidase Inhibitor (MAOI) use * Age under 21 * Use of leukotriene modifier 1 week before study intervention * Having undergone and maintained aspirin desensitization

What they're measuring

24 Hour Urinary Leukotriene-E4 (LTE4)

Timeframe: 24 hour

Trial details

NCT IDNCT03441438

SponsorUniversity of Virginia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-09-01

Contact for this trial

BJ Ferrebee-Ghamandi, MHA

434-243-1558 Bjf8j@hscmail.mcc.virginia.edu

View on ClinicalTrials.gov More Aspirin-Sensitive Asthma With Nasal Polyps trials