TerminatedNot Applicable

Goal of Open Lung Ventilation in Donors

Stopped: Trial no longer feasible

United States154 participantsStarted 2018-07-09

Plain-language summary

The primary goal of this study is to assess whether ventilation of deceased organ donors with an open lung protective ventilatory strategy will improve donor lung utilization rates and donor oxygenation compared to a conventional ventilatory strategy.

Who can participate

Age range13 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Brain death * Authorization for research * ≥13 years of age Exclusion Criteria: * Arterial/Inspired oxygen ratio (PaO2/FiO2) ≤ 150 mmHg * PaO2/FiO2 ≥ 400 mmHg * BMI \> 40 * Hepatitis B surface antigen positive * Hepatitis C positive * Failure to complete donation process * Hemodynamic instability

What they're measuring

Donor lung utilization rate

Timeframe: during donor management period (usually 12-48 hours)

Trial details

NCT IDNCT03439995

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-01

View on ClinicalTrials.gov More Brain Death trials