CompletedNot Applicable

Hyperoxemia and Ventilator-associated Pneumonia

France534 participantsStarted 2018-03-15

Plain-language summary

The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence. * SpO2 will be continuously recorded in order to determine the percentage of time spent with hyperoxemia. * Patients with VAP will be prospectively identified. * Patient characteristics and risk factors for VAP will be prospectively collected. * Oxidant stress will be prospectively investigated in study patients: glutathion peroxidase (GPX), plasmatic superoxyde dismutase (SOD), total plasmatic antioxidant status (SAT) and urinary 8-isoprostanes will be performed at ICU admission, once a week, and at VAP occurrence. Patients with VAP will be compared with those with no VAP

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Adult patients admitted to the ICU * Expected duration of mechanical ventilation \> 48h * Signed informed consent * Social insurance Exclusion Criteria: * Pregnancy or breast feeding * No informed consent * Hyperbaric oxygen treatment * Prisoners and patients under guardianship

What they're measuring

VAP occurrence

Timeframe: 28 days after ICU admission

Trial details

NCT IDNCT03434821

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-04-30

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