A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV

Inclusion Criteria: * Confirmed HIV-infection (documented in medical record) * Age ≥16 years * Confirmed pregnancy, \<28 weeks estimated gestational age (by best obstetric estimate which may include ultrasound or fundal height and LMP) * Live singleton pregnancy * Receiving prenatal care at Mboppi Hospital or Mutengene Hospital * Plan to receive follow up prenatal care and deliver at study facility * Capable of providing written informed consent * Able and agree to come to facility for febrile episodes or acute illness during pregnancy (with reimbursement of transportation costs). * Agree to avoid antimalarial medications outside of study protocol. Exclusion Criteria: * Severe anemia (last hemoglobin \<6) * History of severe adverse reaction to co-trimoxazole or azithromycin * Active medical problem requiring inpatient evaluation at the time of screening * Intention of moving far away from the facility during pregnancy or not likely to return for follow up care or delivery * Signs or symptoms of early or active labor * History of severe cardiac disease (including congestive heart failure, severe valvular disease or arrhythmias).