CompletedPhase 4

Citicholine-Amantadine Trial in Traumatic Brain Injury

Egypt45 participantsStarted 2017-12-07

Plain-language summary

This randomized study aims at comparing between the effects of amantadine, citcholine and its combinations on arousal and behavioral consequences in early phase of moderate Traumatic Brain injury (TBI).

Who can participate

Age range16 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Sustained moderate non-penetrating TBI with GCS of 9-12 Exclusion Criteria: * Patients with mild (GCS \> 12) or severe TBI (GCS \< 9) * Patients suffering from any central nervous system disability prior to the traumatic brain injury * Major medical problems as; major cardiovascular disease or heart failure, renal insufficiency (creatinine clearance, less than 60 ml per minute), liver impairment, * Pregnancy, * More than one seizure in the previous month, * Prior treatment with amantadine, * Allergy to the study drugs.

What they're measuring

Galsgow coma scale

Timeframe: 30 days

Trial details

NCT IDNCT03430817

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-24

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