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Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder

France66 participantsStarted 2018-01-19

Plain-language summary

Up to 50% of Narcolepsy-cataplexy (NC) patients suffer from REM sleep behavior disorder (RBD), a parasomnia. A strong link was found between RBD and impulse control disorders (ICD) in Parkinson disease (PD) patients. ICD are thought to be related to a dysfunction of meso-cortico-limbic pathways which belong to the so called ''reward system''. A recent study in IRMf shows that RBD is associated with impaired reward system. A strong link was found between these two disorders and therefore we believe that RBD is associated with impaired reward system in NC The main objective of this study is to evaluate differences in brain activation between NC patients with and without RBD. The investigators hypothesize that NC patients with RBD have a more severe dysfunction of the reward system (hypoactivation of the meso-cortico-limbic pathway) than patients without RBD.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * \- Men or women, right handed, 18 to 80 years * Patients with type 1 Narcolepsy according to the criteria of the International Classification of Sleep, 3rd version, 2014 * Acceptance of the protocol and signature of a written consent * Social security affiliation Exclusion Criteria: * Previous history of psychosis or psychiatric disease * History of stroke or vascular lesion on MRI. * Perceptual disorder (vision, hearing) may hinder the realization of the protocols, * Dementia defined by a score across Montreal Cognitive Assessment (MoCA) \<26/30. * Major depressive state defined by a score scale Beck Depression Inventory (BDI)\> 14 * Apathy defined by a score ≥ 14 on the Apathy Scale of Starkstein. Patients with a score ≥ this one will be excluded. * Usual contraindications to MRI, knowing that no contrast agent injection is performed. * Pregnant woman.

What they're measuring

Measure of BOLD signal variation in each region of interest

Timeframe: at Month 1

Trial details

NCT IDNCT03425214

SponsorUniversity Hospital, Clermont-Ferrand

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-06-30

Contact for this trial

Patrick LACARIN

04 73 75 11 95 placarin@chu-clermontferrand.fr