Exercise, Fitness and Tumor Profiling in Breast Cancer Patients

Inclusion Criteria: Cohort 1: Breast Cancer Patients * Ages 21-80 years * Female * Histologically confirmed ER receptor positive (\>1% staining), HER2 negative (FISH ratio \<1.8), untreated operable breast cancer * Stage I to II disease * Scheduled for surgical resection by any type of mastectomy or lumpectomy at MSK * Tumor size ≥1cm by preoperative imaging or physical examination * Categorization into self-reported exercise history exposure classifications as follows: (1) exercising: ≥120 minutes of vigorous-intensity exercise/wk for the past 12 months, and (2) sedentary (non-exercising): ≤ 30 minutes of moderate-intensity exercise/week for the past months using the Harvard Health Professionals survey.(34) * Ability to read and understand English * Willing and able to comply with requirements of the protocol Cohort 2: High-Risk Patients * Women at high-risk of breast cancer, as defined by one of the following: * Cytologically confirmed atypical hyperplasia * confirmed LCIS * Being a carrier for BRCA1 and/or BRCA2 * Predicted lifetime risk of breast cancer \>20% based on family history * Predicted 10-year risk of breast cancer of ≥2.31% * Predicted 5-year risk of breast cancer ≥1.67% * Aged 21-80 years old * If a female of child-bearing potential, must not be pregnant or planning to become pregnant during the study. * Women \<50 years old of child-bearing potential must have a negative pregnancy test (urine HCG or serum) within 14 days of enrollment. Exc…