CompletedPhase 4

The Effects of Dexmedetomidine on Intravenous Anesthetic Requirements for Children Undergoing Dental Procedures

Canada88 participantsStarted 2018-03-14

Plain-language summary

The investigators propose to determine the propofol and remifentanil sparing effects of a single dose of dexmedetomidine in the dental population. The investigators plan to do this by performing a blinded study with 4 test groups (3 experimental and 1 control), using BIS monitoring to titrate TIVA infusion to an acceptable depth of anesthesia.

Who can participate

Age range2 Years – 10 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ASA 1-2 * Elective dental surgery * Planned general anesthesia with TIVA * Age 2-10 years Exclusion Criteria: * General anesthesia with inhalation induction * Documented seizure disorder * Cardiac disease * Cardiac rhythm abnormalities * Chronic hypertension * Weight \< 5th centile or \> 95th centile for age * Pre-operative administration of anxiolytics (such as benzodiazepines or opioid analgesics) * Hypersensitivity to dexmedetomidine or any other study medication

What they're measuring

Propofol and remifentanil sparing

Timeframe: Through length of procedure, an average of 1.5 hours

Propofol and remifentanil infusion rate reduction

Timeframe: Through length of procedure, an average of 1.5 hours

Trial details

NCT IDNCT03422978

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-04-01

View on ClinicalTrials.gov More Anesthetic Sparing trials