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Microbiota is Related With Increasing Infection Rates After Splenectomy

China80 participantsStarted 2017-05-01

Plain-language summary

Studies has shown an increasingly infection rate after splenectomy, and there is a potential correlation between microbiota and immune system. investigators suppose that increasingly infection can be associated with the alteration composition of the gut microbiota after splenectomy. It's investigators' aim to discover if any difference of gut microbiota is exist in patients who suffer from traumatic splenectomy compared with normal people, ultimately aim toreduce and mitigation infection rate through controlling gut microbiota.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All the patients underwent an total splenectomy in the First Affiliated Hospital of Harbin Medical University from January 1st, 2015 to May 1st, 2017. Each participant provided a fresh stool sample in hospital when following-up. Exclusion Criteria: * Use antibiotics and probiotics 3 mouth before samples collection. * Other severe abdomen injury * Underwent abdomen organ resection surgery * Other digestive system disease

Questions worth asking your doctor

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1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

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Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Transcriptional changes in gut microbiota

Timeframe: Baseline, 6 months after surgery, 12 months after surgery, 24 months after surgery

Transcriptional changes in plasma LPS levels

Timeframe: Baseline, 6 months after surgery, 12 months after surgery, 24 months after surgery

Trial details

NCT IDNCT03420599

SponsorFirst Affiliated Hospital of Harbin Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-11-25

Contact for this trial

Wei Yunwei

+86-0451-85553099 hydwyw11@hotmail.com

View on ClinicalTrials.gov More Gut Microbiota trials