Modified perforated membrane (MPM) is considered as a modality that could enable participation of periosteal cells and gingival stem cells which could improve the outcomes of guided tissue regeneration more than the use of the traditional occlusive membrane (OM). Simvastatin (SMV) modulates bone formation by increasing the expression of bone morphogenetic protein 2 and angiogenesis. Ethylenediaminetetraacitic acid (EDTA) found to be effective as low ph etchant for smear layer removal and exposing root surface collagen. The investigators compared the clinical and radiographic outcome of SMV gel combined with MPM to SMV gel combined with OM with and without an associated EDTA gel root surface etching for improving bone regeneration in intrabony defects in chronic periodontitis patients. Moreover, evaluation of SMV gingival crevicular fluid (GCF) levels availability for 30 days in cases with and without EDTA root surface etching was performed.
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Probing pocket depth
Timeframe: Baseline to 9 months
Clinical attachment level
Timeframe: Baseline to 9 months
Plaque index
Timeframe: Baseline to 9 months
Gingival index
Timeframe: Baseline to 9 months
Linear measurements
Timeframe: Baseline to 9 months
Radiodensitometric measurements
Timeframe: Baseline to 9 months