Central Nervous System Infections in Denmark (NCT03418441) | Clinical Trial Compass
RecruitingNot Applicable
Central Nervous System Infections in Denmark
Denmark1,900 participantsStarted 2015-01-01
Plain-language summary
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by a prospective registration of clinical characteristics and outcome of all adult (\>17 years of age) patients with community-acquired CNS infections diagnosed and/or treated at departments of infectious diseases in Denmark since 1st of January 2015.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Definitions of central nervous system infections:
For all cases with unproven aetiologies no alternative diagnosis than CNS infection is thought more likely after completed multidisciplinary diagnostic work-up.
Viral meningitis inclusion criteria
\- All patients have to have a clinical presentation consistent with non-bacterial meningitis (e.g. headache, neck stiffness, photo- or phonophobia, fever)
and
Cerebrospinal fluid leukocytes\>10 cells/ml
Patients with viral meningitis with undetermined pathogen have to have:
* CSF leukocytes\> 10/mL and no other more probable diagnosis assessed by the local investigator.
In case of doubt, patients are discussed with the DASGIB secretary and chair or at meetings.
Bacterial meningitis inclusion criteria - All patients have to have a clinical presentation consistent with bacterial meningitis (e.g. headache, neck stiffness, fever, altered mental status)
and
Proven bacterial aetiology (CSF or blood culture/DNA based technology or antigen tests)
Patients with bacterial meningitis in whom the bacteria cannot not be cultured or identified by DNA-based technologies have to have:
\- CSF leukocytes\> 10/mL and no other more probable diagnosis assessed by the local investigator.
In case of doubt, patients are discussed with the DASGIB secretary and chair or at meetings.
Encephalitis inclusion criteria - All patients have to have a clinical presentation consistent with encephalitis (e.g. headache, fever, focal neurological deficit,…