SCOUT Reflector for Tagging Lymph Nodes for Targeted Removal in Patients With Breast Cancer

Inclusion Criteria: * Able to give written informed consent to participate in the study * Patients with a breast cancer diagnosis of any subtype and a biopsy-proven positive axillary lymph node who will be treated first with chemotherapy * Enlarged lymph node and/or clip targetable with image guidance * Patients who are eligible for surgical resection of the primary breast cancer and targeted dissection of the axilla Exclusion Criteria: * More than 3 positive axillary nodes on imaging or matted nodes on clinical exam * Stage IV breast cancer * Pregnant or lactating females * Patients with inflammatory breast cancer * Patients with allergies to isosulfan blue or technetium, which would preclude sentinel node mapping * Patients who have had previous axillary surgery, including sentinel lymph node biopsy