Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions (NCT03410836) | Clinical Trial Compass
UnknownPhase 4
Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions
Canada60 participantsStarted 2019-04-29
Plain-language summary
This study evaluates the impact of intraoperative intravenous lidocaine administered during laparoscopic colorectal surgery on the intraoperative remifentanil consumption as well as postoperative pain and opioid requirements. It will evaluate immune cell activity for 48hours after surgical stress and general anesthesia with or without intravenous lidocaine.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ASA status I, II or III
* Patients older than 18 years
* Colonic surgery
* Classical management of ERAS program patients in our center
Exclusion Criteria:
* Arrhythmia, abnormal electrocardiographic , antiarrhythmic therapy
* Immunosuppressive treatments, corticosteroids or long-term NSAIDs (multiple weekly doses) or during preoperative 48 hours
* conversion intraoperative of a laparoscopic surgical technique to a laparotomy technique
* Pregnant women
* Inability to complete the questions related to this study
* Inability to use hydromorphone postoperative PCA
* Intolerance or allergy to lidocaine, hydromorphone or any other drug that is included in the protocol for perioperative management
Unexpected events leading to the exclusion:
* Difficult unplanned intubation
* Surgical complication requiring aggressive haemodynamic support (vasopressors, inotropes, transfusion)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Reduction of total intraoperative remifentanil consumption by 30% in the intravenous lidocaine ("IVL") group compared with the control group ("C"). Total consumption of remifentanil in mcg.