Measuring Brain Activity of School Age Children (NCT03407729) | Clinical Trial Compass
CompletedNot Applicable
Measuring Brain Activity of School Age Children
United States21 participantsStarted 2018-06-08
Plain-language summary
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
Who can participate
Age range8 Years – 15 Years
SexALL
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Inclusion criteria
✓. For Study Group Children: Birth gestational age between 23-28 weeks and birth weight appropriate for gestational age (AGA) with available oxygen saturation level data recorded continuously from the first day of life to 8 weeks postnatal age (n=11)
✓. For Healthy Control Children: Birth gestational age ≥ 38 weeks gestation and birth weight appropriate for term gestation (n=10) matched by age/sex/race to participating cohort children.
✓. Born in years 2005-2009 (age range will be 8-15 years during the funding period)
✓. Ability of the child to provide assent, with the parent/legal guardian able to provide written informed consent for study procedures.
✓. Sensory and motor capability to complete study tasks (i.e. Grooved Pegboard test). Mental Development index must be \> 80 at 2-year-old follow-up for preterm cohort.
Exclusion criteria
✕. Past history of concussion requiring medical treatment to avoid confounding of MRI data
✕. Current diagnosis of autism.
✕. Child who suffers from claustrophobia (per parent report).
✕. Unable to participate in neuroimaging due to claustrophobia, or medical contraindication to MRI including any implanted medical device, dental braces, surgical clips for aneurysms in the head, heart valve prostheses, electrodes or other metallic objects, pregnancy.
✕. Healthy control children who were treated in the Neonatal ICU in the newborn period for breathing difficulties.
What they're measuring
1
Structural Integrity of Dopaminergic Circuits
Timeframe: 30 minutes
2
Functional Activity During Executive Function Tasks