CompletedPhase 4

Peripheral Nerve Blocks for Above-the-knee Amputations

United States30 participantsStarted 2018-02-09

Plain-language summary

Surgery performed with nerve blocks and sedation may be safer and provide better pain control compared to general anesthesia and opioid therapy in high-risk patient populations such as elderly and troubled with peripheral vascular disease, diabetes, hypertension, coronary artery disease, and chronic obstructive pulmonary disease (COPD).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing above-the-knee amputation or knee disarticulation * Ability to understand and provide informed consent Exclusion Criteria: * Patient refusal or inability to provide informed consent * True allergy, not sensitivity, to any of the following substances: * \- Local anesthetics * \- Propofol or other sedative agents * \- General anesthetic agents * Pregnancy * Severe hepatic impairment * Evidence of infection at or near the proposed needle insertion site * Any sensorimotor deficit, whether acute or chronic, as determined by the PI * Chronic use of opioid medication * BMI ≥ 35

What they're measuring

Peripheral Nerve Block Success as a Primary Anesthetic

Timeframe: Intraoperative period (typically one to three hours)

Trial details

NCT IDNCT03404180

SponsorUniversity of Florida

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-18

Results submitted2025-12-04

View on ClinicalTrials.gov More Peripheral Vascular Diseases trials