Changes in Cytokine Levels After Dextrose Injection in Stage IV Knee Osteoarthritis (NCT03400631) | Clinical Trial Compass
CompletedNot Applicable
Changes in Cytokine Levels After Dextrose Injection in Stage IV Knee Osteoarthritis
Argentina20 participantsStarted 2018-08-01
Plain-language summary
Twenty participants with severe arthritis will be enrolled. For the first week participants will either be injected with dextrose or just have fluid withdrawn for testing. The remaining participants will be given dextrose injection at the end of the week. After one week dextrose injections will be given at one, two, three, four, five, and six months. Fluid will be withdrawn from the knee at time zero, one week, and three months. The hypothesis is that dextrose injection will cause a change in proteins in the knee consistent with improved repair signals, along with improving knee pain and function. .
Who can participate
Age range
21 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Knee pain for at least 6 months.
* Clinically diagnosed knee osteoarthritis.
* Weight-bearing radiograph consistent with high-grade medial compartment cartilage loss (Kellgren-Lawrence Grading Scale level IV).
* Confirmation of exposed subchondral bone by high-resolution knee ultrasonography.
Exclusion Criteria:
* Anticoagulation therapy.
* Inflammatory or post-infectious knee arthritis.
* Systemic inflammatory conditions.
* Knee flexion of less than 100 degrees.
* Knee extension of less than 165 degrees.
* Any Valgus
* Varus more than 15 degrees.
* Any knee injection in the past 3 months.
* BMI more than 40
* Gross synovial folds on ultrasound
* Elevation of sed rate, C reactive protein, rheumatoid factor or antinuclear antibody.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.