RecruitingNot Applicable

Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation

Canada132 participantsStarted 2019-01-23

Plain-language summary

The main purpose of this project is to evaluate the effects of high-intensity interval training (HIIT) compared to moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. Positive findings are vitally important for these patients, given the condition's substantial morbidity, mortality and high economic costs.

Who can participate

Age range40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. persistent or permanent atrial fibrillation;
✓. rate controlled with a resting ventricular rate of equal to or less than 100 bpm;
✓. able to perform a symptom-limited exercise test;
✓. at least 40 years of age (i.e. participants must be 40 years or older);

Exclusion criteria

✕. currently participating in routine exercise training (more than two times per week);
✕. unstable angina;
✕. diagnosed severe mitral or aortic stenosis;
✕. diagnosed hypertrophic obstructive cardiomyopathy with significant obstruction;
✕. pregnant, lactating or planning to become pregnant during the study period;
✕. unable to provide written, informed consent, or
✕. unwilling or unable to return for follow up at week 12.

What they're measuring

Changes in quality of life measured by the physical component summary (PCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36).

Timeframe: baseline to 12 weeks

Changes in exercise capacity measured by VO2peak on a symptom-limited cardiopulmonary exercise test (CPET).

Timeframe: baseline to 12 weeks

Trial details

NCT IDNCT03397602

SponsorOttawa Heart Institute Research Corporation

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-30

Contact for this trial

Jennifer L Reed, PhD

613-696-7392 jreed@ottawaheart.ca

View on ClinicalTrials.gov More Atrial Fibrillation trials

Plain-language summary

Who can participate

Age range40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. persistent or permanent atrial fibrillation;
✓. rate controlled with a resting ventricular rate of equal to or less than 100 bpm;
✓. able to perform a symptom-limited exercise test;
✓. at least 40 years of age (i.e. participants must be 40 years or older);

Exclusion criteria

✕. currently participating in routine exercise training (more than two times per week);
✕. unstable angina;
✕. diagnosed severe mitral or aortic stenosis;
✕. diagnosed hypertrophic obstructive cardiomyopathy with significant obstruction;
✕. pregnant, lactating or planning to become pregnant during the study period;
✕. unable to provide written, informed consent, or
✕. unwilling or unable to return for follow up at week 12.

What they're measuring

Changes in quality of life measured by the physical component summary (PCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36).

Timeframe: baseline to 12 weeks

Changes in exercise capacity measured by VO2peak on a symptom-limited cardiopulmonary exercise test (CPET).

Timeframe: baseline to 12 weeks