RecruitingNot Applicable

Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation

Canada132 participantsStarted 2019-01-23

Plain-language summary

The main purpose of this project is to evaluate the effects of high-intensity interval training (HIIT) compared to moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. Positive findings are vitally important for these patients, given the condition's substantial morbidity, mortality and high economic costs.

Who can participate

Age range

40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. persistent or permanent atrial fibrillation;
. rate controlled with a resting ventricular rate of equal to or less than 100 bpm;
. able to perform a symptom-limited exercise test;
. at least 40 years of age (i.e. participants must be 40 years or older);

Exclusion criteria

. currently participating in routine exercise training (more than two times per week);
. unstable angina;
. diagnosed severe mitral or aortic stenosis;

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changes in quality of life measured by the physical component summary (PCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36).

Timeframe: baseline to 12 weeks

Changes in exercise capacity measured by VO2peak on a symptom-limited cardiopulmonary exercise test (CPET).

Timeframe: baseline to 12 weeks

Trial details

NCT IDNCT03397602

SponsorOttawa Heart Institute Research Corporation

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-30

Contact for this trial

Jennifer L Reed, PhD

613-696-7392 jreed@ottawaheart.ca

View on ClinicalTrials.gov More Atrial Fibrillation trials

Plain-language summary

Who can participate

Age range

40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. persistent or permanent atrial fibrillation;
. rate controlled with a resting ventricular rate of equal to or less than 100 bpm;
. able to perform a symptom-limited exercise test;
. at least 40 years of age (i.e. participants must be 40 years or older);

Exclusion criteria

. currently participating in routine exercise training (more than two times per week);
. unstable angina;
. diagnosed severe mitral or aortic stenosis;

What they're measuring

Changes in quality of life measured by the physical component summary (PCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36).

Timeframe: baseline to 12 weeks

Changes in exercise capacity measured by VO2peak on a symptom-limited cardiopulmonary exercise test (CPET).

Timeframe: baseline to 12 weeks