Agents Intervening Against Delirium in Intensive Care Unit

Inclusion Criteria: * Acute admission to the ICU AND * Age ≥ 18 years AND * Diagnosed delirium with validated screening Tool as either CAM-ICU or ICDSC Exclusion Criteria: * Contraindications to haloperidol * Habitual treatment with any antipsychotic medication or treatment with antipsychotics in the ICU prior to inclusion * Permanently incompetent (e.g. dementia, mental retardation) * Delirium assessment non-applicable (coma or language barriers) * Withdrawal from active therapy * Fertile women (women \< 50) with positive urine human chorionic gonadotropin (hCG) or plasma hCG. * Consent according to national regulations not obtainable * Patients under coercive measures by regulatory authorities * Patients with alcohol-induced delirium (Delirium Tremens)