CompletedNot Applicable

Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects

70 participantsStarted 2016-10-20

Plain-language summary

The quantification of the proteomes : L-plastin, lipocalin and adiponectin was analysed in the subgingival tissue samples of generalized severe chronic periodontitis patients with and without diabetes mellitus.The demographic and the periodontal parameters were assessed and the correlated with the quantification of the proteins. The mRNA expression was analyzed with RT-PCR and the quantification of protein was done using ELISA.

Who can participate

Age range35 Years – 60 Years

SexMALE

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Inclusion criteria

✓. Patients willing to participate in the study.
✓. Male patients within the age group 35 to 60 years.
✓. Patients having ≥ 10 natural teeth.
✓. No history of long term antibiotic use in the past 6 months and no history of diabetes mellitus.

Exclusion criteria

✕. Patients with systemic conditions, such as cardiovascular and respiratory diseases, HIV infection, immunosuppressive patients and patients under chemotherapy.
✕. Smokers and other behavioral factors which may influence the study.
✕. Patients who had undergone periodontal therapy within the previous 6 months.
✕. Female patients (due to hormonal changes and pregnancy which may alter the oral flora).

What they're measuring

mRNA expression of L-plastin,lipocalin and adiponection

Timeframe: 9 months

Trial details

NCT IDNCT03391349

SponsorMeenakshi Ammal Dental College and Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-07-22

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