Trial of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab

Inclusion Criteria: * 18-80 years old * Men or women * Women post-menopausal or with ongoing contraception * Diagnosis of acquired hemophilia A * Patient must be insured * Patient has provided written informed consent prior to enrollment * Patient compliant Exclusion Criteria: * Congenital hemophilia * Ongoing treatment with prednisone \> 20mg/d （or equivalent corticosteroid doses） more than 1 month * Ongoing treatment with prednisone \>0.7mg/kg（or equivalent corticosteroid doses） more than 10 days * Pregnant and breastfeeding women * Allergy to steroid * Immunosuppressive agents treatment within 30 days * Serum transaminase and bilirubin greater than 1.5 times the upper limit of normal value * Hepatitis B surface antigen or hepatitis C antibody or HIV antibody (I + II) or syphilis antibody positive * Patients with diabetes, hypertension, glaucoma, peptic ulcer, herpes zoster, pulmonary infection and so on, who should not be treated with glucocorticoids * Patients with poor compliance * Those who can not take contraceptive measures during the test period * Patient who is considered by the investigator not suitable for clinical study * Thrombocytopenia * Leucocytopenia