Sepsis-3 Study in Northeast Thailand (NCT03379402) | Clinical Trial Compass
CompletedNot Applicable
Sepsis-3 Study in Northeast Thailand
Thailand1,002 participantsStarted 2018-02-01
Plain-language summary
This is an observational study to evaluate the utility of the latest recommendation to define severity of infection for sepsis patients (sepsis-3), and to identify the aetiology and factors associated with outcome of community-acquired sepsis in Northeast Thailand.
Potential study participants will be adult patients who are presented at the hospital with community-acquired sepsis. Clinical specimens (including blood, urine, sputum, throat swabs and pus or wound swab) will be collected from each participant on admission for culture, PCR and serological tests, and other laboratory tests. Participants' treatment will be closely monitored during the duration of their hospital stay. Blood will be again collected at 72 hours after admission. Participants will be contacted at 28 days after admission to determine clinical outcome by phone interview with standardized script.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Males and females 18 years old.
✓. Thai nationality.
✓. Required hospitalization as decided by the attending physician
✓. Documented by attending physician that an infection is the primary cause of illness leading to the hospitalization. These can be infections due to any pathogens (bacteria, viruses, fungi and parasites).
✓. qSOFA (quick Sepsis-related Organ Failure Assessment) score ≥ 2 defined as 2 or more of the following:
Exclusion criteria
✕. Infection is not suspected to be a primary cause of the current illness episode leading to the hospitalization. For example, community-acquired sepsis is considered to be due to stroke, cardiovascular diseases, acute myocardial infarction, cancer, burn, injury, and trauma.
✕. Hospitalized at the study site for this current episode for more than 24 hours before enrollment.
✕. Hospitalized for this current episode for more than 72 hours at another primary/referring hospital