CompletedNot Applicable

Invasive Markers of Staphylococcus Epidermidis

France320 participantsStarted 2018-03-01

Plain-language summary

The purpose of the study is to identify biomarkers allowing the distinction between invasive and non-invasive strains of Staphylococcus epidermidis. This distinction is important to determine if the patient is infected and, as a consequence, if an antibiotic treatment is required.

Who can participate

SexALL

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Inclusion criteria

✓. Hospitalized patient with intravascular device (peripheral or central, venous or arterial, short or long duration) for at least 48 hours before the development of bacteraemia
✓. Presenting a definite infection with S. epidermidis according to the categorization criteria,
✓. An operated patient carrying implanted equipment following orthopaedic surgery, following cardiac surgery or following neurosurgery,
✓. Presenting a definite infection with S. epidermidis according to the categorization criteria occurring in the year following surgery
✓. Hospitalized patient with intravascular device (peripheral or central, venous or arterial, short or long duration) for at least 48 hours before positive blood culture with S. epidermidis
✓. Certain contamination with S. epidermidis according to the categorization criteria,
✓. An operated patient carrying implanted equipment following orthopedic surgery, following cardiac surgery or following neurosurgery,
✓. Presenting a certain contamination to S. epidermidis according to the categorization criteria occurring in the year following surgery

Exclusion criteria

✕. Opposition of the patient or the holders of parental authority (minor patients)
✕. Patient with polymicrobial infection
✕. Patient with a colonized catheter (positive catheter end culture \<103UFC / mL) with no clinical signs of local or general infection and with sterile peripheral blood cultures
✕. Patient with local catheter infection (positive catheter end culture\> 103UFC / mL) with local inflammatory signs only and with sterile peripheral blood cultures
✕. Opposition of the patient or the holders of parental authority (minor patients)
✕. Patient with an infection of material concomitant with a catheter-related infection

What they're measuring

genetic markers of S. epidermidis

Timeframe: at the time of the positive sampling of S. epidermidis

Trial details

NCT IDNCT03374371

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-18

View on ClinicalTrials.gov More Staphylococcus Epidermidis Positive Blood Culture trials