CompletedNot Applicable

Essential Amino Acids and Protein Kinetics During Caloric Deprivation

United States20 participantsStarted 2018-09-01

Plain-language summary

The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined. This study will address that gap in knowledge by examining the resting and post-exercise muscle and whole-body protein kinetic responses to ingesting varying amounts of EAA after a 5 day period of negative energy balance. This study will provide the initial evidence to support the development of a recovery-based food product for military combat rations.

Who can participate

Age range18 Years – 35 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men and women aged 18 - 35 years * Body mass index \< 30.0 kg/m2 * Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO) * Resistance exercise trained defined by self-report as performing ≥ 2 sessions/wk for previous 6 mo * Refrain from taking any nonsteroidal anti-inflammatory drugs (e.g., aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product for 10 days before starting and at least 5 days after completing the study * Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine, and dietary supplement use throughout the entire study period * Supervisor approval for federal civilian employees and non-HRV active duty military personnel working within the US Army Natick Soldier Systems Center Exclusion Criteria: * Musculoskeletal injuries that compromise exercise capability as determined by the USARIEM Office of Medical Support and Oversight (OMSO) * Metabolic or cardiovascular abnormalities, gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.) * Abnormal PT/PTT test or problems with blood clotting * History of complications with lidocaine * Present condition of alcoholism, anabolic steroids, or other substance abuse issues * Blood donation within 8-wk of beginning the study * Pregnancy (self-report or results of urine pregnancy test before body…

What they're measuring

Postprandial, Resting Muscle Protein Synthesis Rates

Timeframe: 3 hour measure of muscle protein synthesis

Postprandial, Post-exercise Muscle Protein Synthesis Rates

Timeframe: 3 hour measure of muscle protein synthesis

How Well Participants Suppress the Degradation of Body Proteins While Stimulating the Growth of New Proteins After Ingesting Varying Doses of EAA at Rest and After Exercise. Net Whole-body Protein Balance

Timeframe: 3 hour measure of whole-body protein balance

Trial details

NCT IDNCT03372928

SponsorUnited States Army Research Institute of Environmental Medicine

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2019-03-20

Results submitted2020-04-20

View on ClinicalTrials.gov More Muscle Protein Synthesis trials

Plain-language summary

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Postprandial, Resting Muscle Protein Synthesis Rates

Timeframe: 3 hour measure of muscle protein synthesis

Postprandial, Post-exercise Muscle Protein Synthesis Rates

Timeframe: 3 hour measure of muscle protein synthesis

Timeframe: 3 hour measure of whole-body protein balance