Test of an Inhibitory Learning Model of Extinction in Treatment of Anxious Youth (NCT03372915) | Clinical Trial Compass
CompletedNot Applicable
Test of an Inhibitory Learning Model of Extinction in Treatment of Anxious Youth
United States28 participantsStarted 2018-01-31
Plain-language summary
Recently, basic research conducted in adults has revealed that fear extinction, or the weakening of a learned fear response, may be best explained by principles of "inhibitory learning." New guidelines for the clinical practice of exposure therapy for anxiety disorders have arisen from research on inhibitory learning, but these guidelines have not yet been empirically tested in youth with anxiety disorders. The overall goal of this research is to investigate the acceptability, feasibility, and efficacy of conducting exposure therapy for anxiety disorders in youth according to clinical guidelines developed from basic research on inhibitory learning principles, using a pilot randomized controlled trial design.
Who can participate
Age range
7 Years – 17 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Primary or secondary diagnosis of an anxiety disorder
. Ability of both child and caregiver to read and understand English
. Ability of child and at least one caregiver to attend weekly sessions
Exclusion criteria
. Diagnosis of autism spectrum disorder, intellectual development disorder, or limited cognitive functioning (i.e., documented Intelligence Quotient \[IQ\]\<80).
. Diagnosis of a psychotic disorder or bipolar disorder
. Severe and current suicidal ideation, history of suicide attempt in past six months, or frequent and persistent self-injurious behavior
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Percentage of Exposure Refusals (Feasibility Measure)
Timeframe: Treatment weeks 5, 6, 7, and 8
2
Change in Latency to Initiating Exposure (Feasibility Measure)
Timeframe: Treatment weeks 5, 6, 7, 8
3
Early Treatment Termination (Feasibility Measure)
Timeframe: Measure will be collected following the patient's termination from treatment
4
Change in Homework Completion (Feasibility Measure)