The PrISICE Clinical Trial (Pre-Implantation Screening and Investigation on the Cryopreservation of Embryos)

Inclusion Criteria: * Scheduled to undergo in vitro fertilization for treatment of infertility (1st or 2nd "fresh" attempt); subject can have had no more than one prior failed "fresh" IVF cycle * Couple able to participate in a research project * Able to understand study requirements * Willing to sign informed consent * Able to return for required follow-up * Access to telephone * Ability to read and write * Normal uterine cavity evaluation within one year of enrollment Exclusion Criteria: * Medical conditions which may complicate treatment * No plans to undergo embryo transfer * Medical contraindication to the transfer of more than a single embryo (i.e. congenital uterine anomaly). * Concurrent participation in any other interventional trial * Recurrent pregnancy loss * Known chromosomal abnormality (e.g. translocation) * Pre-implantation genetic diagnosis requiring blastocyst biopsy