CompletedPhase 4

Efficacy of IV Acetaminophen Versus Oral Acetaminophen

United States214 participantsStarted 2018-08-08

Plain-language summary

The aim of this study is to determine whether intravenous acetaminophen compared to enteric acetaminophen offers increased efficacy in patients who are scheduled for laparoscopic donor nephrectomy and for patients scheduled for robot-assisted, laparoscopic nephrectomy for cancer at the University of Rochester Medical Center. The standard surgical and post-operative care, including post-operative pain management will not be altered.

Who can participate

Age range18 Years – 89 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Be at least 18 years old * Be scheduled for donor nephrectomy or robot-assisted, laparoscopic nephrectomy for cancer at University of Rochester Medical Center * Have cognitive ability to verbally rate their pain on the Numeric Rating Scale (NRS). Exclusion Criteria: * Age younger than 18 years old or older than 90 years old * Pregnancy (Pre-operative pregnancy test is standard of care for all elective operating room cases) * Weight less than 50 kg * Epidural use * History of known liver disease. * Patient unable to take enteral medications. * Be taking opioid medications chronically.

What they're measuring

Total Opioid Dose (MME) Used in 24 Hours

Timeframe: 20 to 24 hours post-operatively

Trial details

NCT IDNCT03365622

SponsorUniversity of Rochester

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-10

Results submitted2025-04-10

View on ClinicalTrials.gov More Nephrectomy trials