CompletedNot Applicable

Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome

Japan179 participantsStarted 2017-11-07

Plain-language summary

The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status compared to continuing cigarette smoking. Note: "IQOS" is the Tobacco Heating System (THS) with Marlboro Heatsticks, marketed in Japan under the brand name IQOS

Who can participate

Age range30 Years

SexALL

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Inclusion criteria

✓. Patient is aged ≥ 30 years old.
✓. Patient has smoked on average at least 10 commercially available cigarettes per day for at least 5 years
✓. Patient has generalized chronic periodontitis (i.e., more than 30% of diseased teeth with a PD ≥ 4 mm).

Exclusion criteria

✕. Patient has self-reported history of diagnosed systemic diseases (e.g., stroke or acute cardiovascular event within the last 5 years, diabetes, active cancer).
✕. Patient received root planing therapy within the 6 months prior to Visit 1.
✕. Patient received surgical periodontal therapy within 3 years prior to Visit
✕. Patient was treated within the 3 months prior to Visit 1 with systemic antibiotics or was treated with topical antibiotics applied in the mouth.
✕. Continuous systemic use of steroidal or non-steroidal anti-inflammatory drugs for more than 20 days during the past 30-day period (except for low dose aspirin, i.e., ≤300 mg).
✕. Female patients who are pregnant, breast-feeding, or planning a pregnancy within the course of the study.

What they're measuring

Periodontal Pocket Depth (PD) Change From Baseline at 6 Months

Timeframe: At 6 months

Trial details

NCT IDNCT03364751

SponsorPhilip Morris Products S.A.

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2018-12-21

Results submitted2020-11-11

View on ClinicalTrials.gov More Periodontal Diseases trials