Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

Inclusion Criteria: * Pathologically confirmed diagnosis of liposarcoma; all subtypes are eligible * Sufficient archival tissue available for correlative studies; submission of formalin-fixed paraffin-embedded (FFPE) tumor tissue from a previous biopsy or resection is required, and the most recent specimen is preferred; if a FFPE block cannot be provided, then 10 unstained, positively-charged slides of 4-5 um thickness must be submitted; if insufficient archival tissue is available, a repeat biopsy will be necessary * Primary or recurrent retroperitoneal, scrotal/spermatic cord or abdominal tumor * For subjects between the ages of 12-18 years only, body surface area (BSA) must be \>= 1.5 m\^2 * All sites of disease must be resectable or borderline resectable as assessed by a surgical oncologist with experience in retroperitoneal sarcoma resection after discussion in our institutional multidisciplinary sarcoma tumor board conference * All sites of disease must be targetable with intensity-modulated radiation therapy (IMRT) with acceptable morbidity and without exceeding normal tissue dose constraints as assessed by a radiation oncologist * Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 * Subjects of childbearing potential must have a negative urine beta-human chorionic gonadotropin (beta-hCG) pregnancy test at time of screening * Fridericia's correction formula (QTcF) interval on standard 12-lead electrocardiography (ECG) parameters at screeni…