CompletedNot Applicable

Oxygen Extraction and Delivery in Elderly During Major Surgery

Sweden20 participantsStarted 2017-11-27

Plain-language summary

This clinical observational study investigates perioperative oxygen consumption and delivery in elderly patients undergoing major surgery. The primary objectives are to characterise the perioperative oxygen delivery, consumption and potential markers of oxygen debt. Secondary objective is to estimate the correlation between oxygen delivery/consumption and postoperative outcomes to guide the design of a future trial.

Who can participate

Age range65 Years

SexALL

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Inclusion criteria

✓. Men and women aged ≥65 years
✓. Major/complex surgery (BUPA AXA classification of surgical severity)
✓. Central and arterial venous catheterization for hemodynamic monitoring.
✓. Written informed consent
✓. Available research team for the measurements If two subjects are eligible the elder one will be chosen. If there are two subjects eligible of different gender and almost the same age, the subject with a gender that is underrepresented by two or more will be chosen. This is consistent with the purpose of including subjects with as high age as possible without interfering with recruitment.

Exclusion criteria

✕. Concomitant medication with Lithium (interferes with calibration of the LiDCO monitor)
✕. Weight≤ 40 kg.
✕. Not possible to establish arterial or central venous line.
✕. Planned postoperative care at high-dependency unit (POP/IMA) \<12hrs.

What they're measuring

oxygen consumption

Timeframe: prior to and 15 minutes after anaesthesia induction

Trial details

NCT IDNCT03355118

SponsorKarolinska Institutet

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-03-23

View on ClinicalTrials.gov More Impaired Oxygen Delivery trials