CompletedNot Applicable

Genetic Screening and Assisted Oocyte Activation in Couples with Diminished/aberrant Embryonic Development.

Belgium42 participantsStarted 2018-01-15

Plain-language summary

This is an interventional comparative study at the Department of Reproductive Medicine at Ghent University Hospital. Patients with previous embryo developmental problems are eligible for the study. Patients will undergo an ICSI-AOA treatment and will also be screened for genes important in the oocyte activation and embryonic development process. Also, the calcium releasing pattern of the patients' spermatozoa will be investigated.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients with one or more previous ICSI cycles (UZ Gent) AND * patients with: * complete developmental arrest (no transfer), or * complete developmental delay (no morula/blastocyst on Day 5), or * significantly reduced blastocyst formation (≤15%) * willing and able to give informed consent Exclusion Criteria: * patients which went for oocyte or sperm donation * patients with severe male infertility or low fertilization (\<33%) after ICSI * cycles requiring surgical sperm recovery procedures

What they're measuring

Blastocyst rate

Timeframe: 5 days after oocyte retrieval

Trial details

NCT IDNCT03354013

SponsorUniversity Hospital, Ghent

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-01-31

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