Active — Not RecruitingNot Applicable

BRCA Founder OutReach (BFOR) Study

United States5,412 participantsStarted 2017-11-10

Plain-language summary

The purpose of this study is to learn how to provide BRCA gene testing to a larger number of people as well as to make testing part of a person's regular medical care.

Who can participate

Age range25 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Self-reported age ≥ 25 * Self identify as having at least one of their four grandparents as Ashkenazi Jewish * Has medical insurance * Able to understand and read the English-language * Zip code falls within the catchment areas of the phase of the study (e.g. New York City, Boston, Philadelphia, Los Angeles) accessible to a BFOR designated provider Exclusion Criteria: * Under age 25 * No Ashkenazi Jewish ancestry * Does not have insurance * Has previously had medical BRCA testing ordered by a health care provider

What they're measuring

Proportion of individuals receiving a standardized program of pretest education who then proceed to genetic testing

Timeframe: Up to 1 year

Proportions of individuals who choose to receive the results through their primary care providers or through the study-provided expert staff

Timeframe: Up to 1 year

Psychosocial impact of genetic population screening utilizing a digital health solution

Timeframe: Up to 1 year

Facilitators and barriers to engaging primary care providers (PCPs) in the BRCA1/2 results disclosure process

Timeframe: Up to 1 year

Participant health updates in personal familial cancer diagnosis and genetic testing depending on method of results communication

Timeframe: Up to 1 year

Trial details

NCT IDNCT03351803

SponsorMemorial Sloan Kettering Cancer Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-05-10

View on ClinicalTrials.gov More BRCA1 Mutation trials