Active — Not RecruitingNot Applicable

BRCA Founder OutReach (BFOR) Study

United States5,412 participantsStarted 2017-11-10

Plain-language summary

The purpose of this study is to learn how to provide BRCA gene testing to a larger number of people as well as to make testing part of a person's regular medical care.

Who can participate

Age range

25 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Self-reported age ≥ 25 * Self identify as having at least one of their four grandparents as Ashkenazi Jewish * Has medical insurance * Able to understand and read the English-language * Zip code falls within the catchment areas of the phase of the study (e.g. New York City, Boston, Philadelphia, Los Angeles) accessible to a BFOR designated provider Exclusion Criteria: * Under age 25 * No Ashkenazi Jewish ancestry * Does not have insurance * Has previously had medical BRCA testing ordered by a health care provider

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Proportion of individuals receiving a standardized program of pretest education who then proceed to genetic testing

Timeframe: Up to 1 year

Proportions of individuals who choose to receive the results through their primary care providers or through the study-provided expert staff

Timeframe: Up to 1 year

Psychosocial impact of genetic population screening utilizing a digital health solution

Timeframe: Up to 1 year

Facilitators and barriers to engaging primary care providers (PCPs) in the BRCA1/2 results disclosure process

Timeframe: Up to 1 year

Participant health updates in personal familial cancer diagnosis and genetic testing depending on method of results communication

Timeframe: Up to 1 year

Trial details

NCT IDNCT03351803

SponsorMemorial Sloan Kettering Cancer Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-05-10

View on ClinicalTrials.gov More BRCA1 Mutation trials

Who can participate

Age range

25 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Proportion of individuals receiving a standardized program of pretest education who then proceed to genetic testing

Timeframe: Up to 1 year

Proportions of individuals who choose to receive the results through their primary care providers or through the study-provided expert staff

Timeframe: Up to 1 year

Psychosocial impact of genetic population screening utilizing a digital health solution

Timeframe: Up to 1 year

Facilitators and barriers to engaging primary care providers (PCPs) in the BRCA1/2 results disclosure process

Timeframe: Up to 1 year

Participant health updates in personal familial cancer diagnosis and genetic testing depending on method of results communication

Timeframe: Up to 1 year