Active — Not RecruitingNot Applicable

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

United States40 participantsStarted 2017-09-01

Plain-language summary

This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.

Who can participate

Age range25 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Type 2 diabetes (T2DM) * Age: 25-80 years old * Vitamin 25(OH)D3 levels \<20 or \>30 ng/ml. * HbA1c: 5.5%-9.5% * Blood Pressure: \<160/100 mm Hg on BP lowering medications and * Blood Pressure: \>120/80 to 160/100 mmHg without BP lowering medications Exclusion Criteria: * Recent weight loss of more than 5% within 3 months prior to screening * Current Pregnancy * Hypercalcemia * Previous heart attack and stroke * Heart failure * Atrial fibrillation * Heavy alcohol consumption * Extreme diets (Atkins, South Beach) * Chronic renal failure: stage 4 or worse * \>2 + proteinuria on urine sample * Chronic diseases known to affect immunity

What they're measuring

Renin production by monocytes

Timeframe: 2 weeks

Trial details

NCT IDNCT03348280

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-31

View on ClinicalTrials.gov More Diabetes Mellitus, Type 2 trials