Testosterone and Long Pulse Stimulation After SCI

Inclusion Criteria: * Traumatic motor complete SCI and level of injury of T10 and below * Only participants with lower motor neuron (LMN) denervation as determined by EMG testing * Participants must also have an absence of reflexes, denervation of both knee extensor muscles * Tolerance to LPWS paradigm * Both knee extensors will also have to be unresponsive (i.e., no observed tetanic contraction or twitches) to standard electrical stimulation procedures (stimulation frequency: 30 Hz; pulse duration:450 s and amplitude of the current:200 mA) * All participants will undergo International Standards for Neurological Classification of SCI (ISNCSCI) examination for neurological level and function and only those with American Spinal Injury Classification (AIS A and B; i.e. motor deficit below the level of injury) Exclusion Criteria: * Diagnosis of neurological injury other than SCI * Pre-existing medical conditions will be excluded (cardiovascular disease, uncontrolled type II DM and those on insulin requirements) or other concurrent medical conditions judged to be contraindicated by the site physician. * Hematocrit above 50% and severe urinary tract infection or symptoms * Those with hyper-physiological testosterone level above 800 ng/dl * Those who will fail to tolerate the LPWS paradigm * Progressive condition that would be expected to result in changing neurological status * Lower extremity fracture around the knee joint (distal femur or proximal tibia) within the last 2 year…