UnknownPhase 4

Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve Surgery

Brazil108 participantsStarted 2015-02

Plain-language summary

The purpose of this study is evaluate the effect of prophylactic desmopressin on blood coagulation parameters and postoperative bleeding in patients undergoing valve cardiac surgery with cardiopulmonary bypass.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Valve cardiac surgery with cardiopulmonary bypass. * Written informed consent Exclusion Criteria: * Reoperative valve surgery * Hematocrit \< 35% * Ventricular dysfunction (EF \< 40%) * Infection * Body mass index \> 35 * Renal impairment (Creatinin \> 2mg/dL) * Antiplatelet administration within 10 days preceding study surgery * Participation in another interventional clinical study within 30 days * Known or suspected hypersensitivity to the desmopressin * Coagulopathy (INR \> 1.5)

What they're measuring

Change in coagulation parameters

Timeframe: Coagulation parameters will be performed: T0: preoperative period; T1 - 2 hours after desmopressin or placebo administration; T2 - 24 hours after desmopressin or placebo administration

Postoperative blood loss

Timeframe: 48 hours

Trial details

NCT IDNCT03343418

SponsorInstituto do Coracao

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2017-11

View on ClinicalTrials.gov More C.Surgical Procedure; Cardiac trials