CompletedNot Applicable

Neurovascular Changes Induced by Chemotherapy

Brazil16 participantsStarted 2016-02-22

Plain-language summary

The purpose of the present study was to test the hypothesis that doxorubicin and cyclophosphamide adjuvant chemotherapy (CHT) acutely induces neurovascular and hemodynamic changes in patients with breast cancer. To test this hypothesis, women with breast cancer (stage II-III) underwent two experimental sessions, saline (SL) and CHT. In the CHT session, doxorubicin (60 mg/m2) and cyclophosphamide (600mg/m2) were administred in 45 min. In the SL session, a matching saline volume to that of the CHT session was infused over 45 min.

Who can participate

Age range35 Years – 65 Years

SexFEMALE

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Inclusion Criteria: * Breast cancer patients and prescription of adjuvant chemotherapy with antracycline and cyclophosphamide Exclusion Criteria: * Metastic disease * Hypercholesterolemia * Diabetes * Hypertension * Severe lymphedema * Renal insufficient * Heart failure * Chronic liver disease * Obesity, and treatment with some medications that inhibit cardiotoxicity, as beta-blocker angiotensin converting enzyme, statin, losartan and antioxidants.

What they're measuring

Neural change induced by chemoterapy

Timeframe: 10 min

Trial details

NCT IDNCT03339804

SponsorUniversity of Sao Paulo General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12-01

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