CompletedNot Applicable

Inflammasomes in Cell Death in FTMH, ERM, and RRD

United States41 participantsStarted 2017-09-08

Plain-language summary

Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane. The investigators are collecting vitreous and subretinal fluid samples from patients with these conditions and evaluating activity of the inflammasome pathway with established assays.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Patient of the Wills Eye Hospital Retina service and Mid-Atlantic Retina offices.
✓. Volunteer patients age 18 years and older.
✓. Healthy enough to participate in the study.
✓. Willing and able to consent to participation in the study.
✓. Diagnosis of rhegmatogenous retinal detachment treated with external drainage of subretainl fluid, rhegmatogenous retinal detachment treated with pars plana vitrectomy, or full thickness macular hole treated with pars plana vitrectomy

Exclusion criteria

✕. Presence of tractional retinal detachment
✕. History of trauma
✕. Presence of proliferative vitreoretinopathy
✕. History of prior retinal detachment repair or any prior retina surgery or laser treatment e. Any preexisting retinal disease (including diabetic retinopathy, age related macular degeneration, retinal vein or artery occlusion, other retinal vascular disease, inherited retinal degeneration, uveitis)

What they're measuring

Presence of inflammasomes and their active products

Timeframe: Day of surgery

Trial details

NCT IDNCT03332758

SponsorAllen C. Ho, MD

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-04-10

View on ClinicalTrials.gov More Retinal Detachment trials