Racial/Ethnic Differences in Microneedle Response

Inclusion Criteria: * Subjects will be healthy men and women between 18 - 50 years of age who identify as African American or Black, Asian, Hispanic or Latino, American Indian/Alaska Native, Native Hawaiian/Other Pacific Islander, Caucasian/White, bi-/multiracial. Exclusion Criteria: * Unable to give consent * Severe general allergies requiring chronic treatment with steroids or antihistamines * Previous adverse reaction to microneedle insertion * Known allergy or adverse reaction to medical tape, adhesive, or aloe vera * Anyone with inflammatory diseases of the skin or diseases that alter immune function * Anyone taking any medications that impair the immune system will be excluded (contraceptives, vitamins, and topical products on the face will be allowed) * Anyone with current malignancy or history of malignancy present at the treatment site (upper arm) * Anyone with any of the following present at the treatment site (upper arm): eczema or scaling, inflammation, erythema, edema, blisters * Anyone with uncontrolled mental illness that would, in the opinion of the physician, affect their ability to understand or reliably participate in the study * Anyone taking medications in the following therapeutic classes will be excluded: HMGCoA reductase inhibitors ("statins"), oral or topical steroids, oral antibiotics, topical antibiotics at the local treatment site, topical antihistamines at the local treatment site, beta-blockers, and systemic or topical NSAIDS/analgesics * Anyo…