High Intensity Focused Ultrasound in Uterine Myoma

Inclusion Criteria: * Premenopausal (FSH \< 40 IU/L) * Symptomatic uterine fibroids * Willing to contracept during study period Exclusion Criteria: * Pregnant or willing to be pregnant in future * Cancer in female reproductive organ is suspected or diagnosed * Inflammation in female reproductive organ * Poorly controlled systemic disease * Hematocrit \< 25% * Glomerular filtration rate(GFR) \<= 30ml/min * Cannot tolerate contrast-enhanced MR or Contrast-enhanced ultrasound(CEUS) * Cannot lie down * Previous treatment for leiomyoma, any of ① myolysis, ② myomectomy within 1 year, ③ hormonal therapy longer than 7 days within 4 weeks * Cannot count the number or measure volume of leiomyoma using MRI * Leiomyomas are inadequate (location, volume, number) for intervention * Diameter of leiomyoma is over 5 cm * Leiomyoma is not enhanced * Lactating women * Cannot communicate properly * Participating or have participated in other trials within 30 days