Cognitive Remediation Therapy for Brain Tumor Patients: Improving Working Memory (NCT03323450) | Clinical Trial Compass
CompletedNot Applicable
Cognitive Remediation Therapy for Brain Tumor Patients: Improving Working Memory
United States20 participantsStarted 2017-10-20
Plain-language summary
To investigate a computer-based Cognitive Remediation Therapy (CRT) for brain tumor patients at the Massey Cancer Center on measures of cognitive functioning (e.g., working memory, attention, processing speed, language, visuospatial functioning, immediate and delayed memory, or executive functioning) over time.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Confirmed primary brain tumor diagnosis via MRI and their neuro-oncologist
* A minimum of 2 months post-surgical resection or biopsy(if applicable)
* and/or a minimum 1 month post radiation treatment (if applicable)
* Karnofsky performance status more than 60
* Estimated intelligence at least 80 (standard score)
* Demonstrated attention difficulties (T-score of at least 65 on attention questionnaire or 1 or more standard deviations below mean on direct attention measures)
* No history of cognitive disorder
* No history of mood disorder
* Predicted life expectancy of at least 12 months
* Computer capability at home or provided a departmental iPad Mini to borrow for study purposes
* Primarily English speaking
* Aged 18+ (for which there is available age-adjusted neuropsychological testing standardization / normative data)
Exclusion Criteria:
* If they are not patients of Massey Cancer Center or do not meet the inclusion criteria listed above
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Treatment enrollment rates
Timeframe: 6 months
2
Attrition rates
Timeframe: 6 months
3
Change in scores on Behavior Rating Inventory of Executive Function-Adult (BRIEF-A) over time
Timeframe: Baseline to 6 months
4
Change in scores on Conners' Continuous Performance Test - Third Edition (CPT-3) over time
Timeframe: Baseline to 6 months
5
Change in scores on Delis-Kaplan Executive Function System (D-KEFS) over time
Timeframe: Baseline to 6 months
6
Change in scores on Repeatable Battery for the Assessment of Neuropsychological Status (RBANS-Update A, B, C, or D) over time
Timeframe: Baseline to 6 months
7
Scores on Test of Premorbid Functioning (TOPF) at baseline