TerminatedNot Applicable

Study of Functional Networks in Resting fMRI

Stopped: Deadline of the end date of the inclusions

37 participantsStarted 2011-12-14

Plain-language summary

The primary purpose is to compare with resting fMRI the functional networks of rest (RTS) in unipolar depression and in bipolar depression. Hypothesis : the main objective of this work is to compare with the rest fMRI the Rest Functional Networks (RFN) in the unipolar depression and in the bipolar depression in order to identify specific biomarkers for each affection. The general hypothesis of this work is that intra- and inter RFN connectivity is different between bipolar patients and unipolar patients. Specifically the investigators assume that connectivity within the default mode network (including ventral mediofrontal cortex, subgenual cingulate cortex, inferior parietal cortex, posterior cingulate cortex) will be increased in unipolar patients compared to bipolar patients.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Unipolar and bipolar depressed patients including patients with type I and type II bipolar disorders. * Patients in an acute depressive state (according to DSM-IV criteria). * Men or Women with age between 18 to 65 years. * Patients with unipolar depression must fullfill Mitchel's criteria for unipolar depression. * MADRS score \> 22 * YMRS score \< 12 * Mean duration of depressive episode \< 1 year * in-patient or out-patient Healthy volunteers matched for age and socio-educational level, without personal history of unipolar or bipolar depression and without psychiatric disorders Exclusion Criteria: Patients and controls: * Bipolar disorder with rapid cycling * Suicidal thoughts with score \> 3 at the MADRS item 'suicide' * Depression with psychotic features * Psychiatric co-morbidity including other AXIS-1 disorders (OCD, schizophrenia, social phobia) and borderline personality disorder * Substance and alcohol abuse or dependance * Recent treatment with ECT (\< 6 months) * Previous history of Brain Traumatic Injury; neurological disorders (multiple sclerosis, parkinson's disease, stroke) or disorders associated with abnormal MRI (lupus, Behcet's disease) * Contra-indication of MRI: pregnancy; tatoos; claustrophobia * Patient hospitalized under legal condition * Patient that requires an important sedation due to anxiety * Bipolar patients that requires at less 3 mood stabilizers * Patient receiving a new antidepressant since more than 10 days * Pat…

What they're measuring

Bold signal and connectivity coefficients within and between neural networks

Timeframe: one day (within 16 days after inclusion)

Trial details

NCT IDNCT03323073

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-11-18