CompletedPhase 4

Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel

Saudi Arabia24 participantsStarted 2017-02-15

Plain-language summary

assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planning (SRP) in chronic moderate to severe periodontitis patients as indicated by expression of Human Beta Definsin-2 (HBD2) in gingival crevicular fluid (GCF).

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients should be systemically healthy with moderate to severe chronic periodontitis of more than 4 mm probing depth in at least two sites in different quadrants. * Patient should exhibit no known allergies * Participants should have the ability to attend the hospital regular intervals. Exclusion Criteria: * pregnancy * nursing * hypertension * patient with chronic diseases such as diabetes mellitus or rheumatoid arthritis. -Participants should not be under antibiotics and\\or had receive any periodontal therapy for the last 6 months. * Participants should not taking drugs that could affect the state of the gingival tissues. * Participants must not be undergoing orthodontic therapy, caries free * Participants must not be using any other supplemental plaque control measures like mouthwashes. * Participants should not have the habit of taking alcohol, smoking or chewing tobacco and do not suffer from any systemic disease.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Clinical Attachment Level (CAL) change

Timeframe: baseline, six weeks, 12 weeks

Probing Depth change

Timeframe: baseline, six weeks, 12 weeks

Gingival Index change (Loe and Silness, 1963)

Timeframe: baseline, six weeks, 12 weeks

Plaque index change (Loe and Silness, 1964)

Timeframe: baseline, six weeks, 12 weeks

Papillary Bleeding Index change (Muhlemann, 1977)

Timeframe: baseline, six weeks, 12 weeks

Trial details

NCT IDNCT03311906

SponsorRiyadh Colleges of Dentistry and Pharmacy

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-08-15

View on ClinicalTrials.gov More Periodontitis trials

Plain-language summary

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Clinical Attachment Level (CAL) change

Timeframe: baseline, six weeks, 12 weeks

Probing Depth change

Timeframe: baseline, six weeks, 12 weeks

Gingival Index change (Loe and Silness, 1963)

Timeframe: baseline, six weeks, 12 weeks

Plaque index change (Loe and Silness, 1964)

Timeframe: baseline, six weeks, 12 weeks

Papillary Bleeding Index change (Muhlemann, 1977)

Timeframe: baseline, six weeks, 12 weeks