UnknownNot Applicable

The Efficiency and Safety of Sodium Bicarbonate on Uric Acid in Patients With Asymptomatic Hyperuricemia or Gout

104 participantsStarted 2017-11-01

Plain-language summary

This study evaluate the serum uric acid lowering effect of sodium bicarbonate as well as its safety in patients with asymptomatic hyperuricemia or gout. Half of the participants will receive sodium bicarbonate only, while the other half receive none.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. Sign informed consent form;
✓. Serum uric acid ≥420mmol/L;
✓. Within the age range of 18-65 years old;
✓. Within the BMI range of 18-30kg/m2;
✓. Both men and women are eligible

Exclusion criteria

✕. General situations
✕. Taking part in another trail
✕. Gout flares happening over the last one month;
✕. Administration of medications over the last one month, including: allopurinol, Febuxostat,benzbromarone, and/or sodium bicarbonate；
✕. urine pH\>7.0;
✕. Hepatic function：ALT and/or AST and/or TB\>1.5 upper limit of normal (ULN);
✕. Renal function：eGFR\<60 ml/min for MDRD and/or urine protein\>0.5g/24h；
✕. Hypertension：\>140/90mmHg;

What they're measuring

Serum uric acid

Timeframe: 1 month after randomization

Trial details

NCT IDNCT03306758

SponsorShanghai Zhongshan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-07-31

View on ClinicalTrials.gov More Asymptomatic Hyperuricemia trials