TerminatedNot Applicable

Using Intradialytic Blood Pressure Slopes to Guide Ultrafiltration

Stopped: Funding Expired

United States14 participantsStarted 2017-11-01

Plain-language summary

This study is an open label randomized clinical trial that comparing intradialytic blood pressure slope-based ultrafiltration prescriptions to standard care in the chronic fluid management of maintenance hemodialysis patients. It also includes a cross sectional component evaluating the associations between intradialytic blood pressure slopes ascertained over 2 week periods with measurements of extracellular water/body weight obtained with multifrequency bioimpedance spectroscopy.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age greater than 18 years * End Stage Renal Disease on Maintenance Hemodialysis * Hypertension defined as systolic blood pressure \> 140 mmHg pre-dialysis or \>130 mmHg post dialysis Exclusion Criteria: * Hemodialysis Vintage \< 1 month * Pregnancy * Nadir Systolic Blood Pressure \< 95 mmHg * Pre or Post dialysis systolic blood pressure \> 180 mmHg * Decrease in systolic blood pressure \>60 mmHg from pre to post dialysis * Ultrafiltration rate \>13 mL/kg/hr * Peridialytic Midodrine Use * Intradialytic Clonidine use * Documented Antihypertensive Medication Non-adherence Bioimpedance will not be peformed on patients with * amputated arms or legs * cardiac defibrillator or pacemaker * presence of metal prostheses

What they're measuring

Change in Mean Ambulatory Systolic Blood Pressure

Timeframe: Baseline, 4 months

Trial details

NCT IDNCT03303391

SponsorUniversity of Texas Southwestern Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-01

Results submitted2021-12-21

View on ClinicalTrials.gov More ESRD trials