UnknownNot Applicable

Mechanical Stimulation of the Ovary for Infertility Treatment in Patients With Very Low Ovarian Reserve

10 participantsStarted 2017-10-20

Plain-language summary

Examine the possibility that mechanical stimulation and ovarian fragmentation in women with premature ovarian failure or low ovarian reserve intended for egg donation may cause early follicular recruitment and increase chances of achieving pregnancy through IVF.

Who can participate

Age range

21 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy women, aged 21-40. with premature ovarian failure. * Healthy women, with poor ovarian reserve, aged 38-45, undergoing IVF Low ovarian response: recruitment of up to three eggs in previous treatments. * After the failure of at least 4 cycles. * Two functioning ovaries, follicular and hormonal response of both ovaries in prior therapies. * Women candidates for egg donation, and seeking further treatment before switching to egg donation. Exclusion Criteria: * Women with kidney disease. * Women with infertility factors other than ovarian failure, such as endometriosis, PCOS, male factor. * Women with one non-functioning ovary, or that was removed. * Women with an intrauterine or pelvic pathology.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Menstrual cycle surveillance

Timeframe: 2 years

AMH

Timeframe: 2 years

Estradiol

Timeframe: 2 years

Antral follicular count

Timeframe: 2 years

IVF outcomes

Timeframe: 2 years

FSH levels

Timeframe: 2 years

IVF outcomes fertilization rates

Timeframe: 2 years

IVF outcomes

Timeframe: 2 years

Trial details

NCT IDNCT03298750

SponsorSheba Medical Center

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2019-09-01

Contact for this trial

Alon Kedem, MD

972543456953 kedem2001@gmail.com

View on ClinicalTrials.gov More Ovarian Stimulation trials

Who can participate

Age range

21 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.