CompletedNot Applicable

Diffusion MRI in Cervical Spondylotic Myelopathy (CSM)

United States71 participantsStarted 2018-01-29

Plain-language summary

Patients who have been diagnosed with Cervical Spondylotic Myelopathy will be asked to undergo an MRI using diffusion basis spectrum imaging (DBSI) technology. The patients will have this MRI preoperatively and at 24 months postop. The investigators believe that with this imaging, biomarkers will be able to be seen to assist in prediction of long term outcomes in patients with spinal cord compression. These patients will be compared to healthy cohorts who will also undergo an MRI using the DBSI technology.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion Criteria: * History of ongoing spinal cord compression, * clinical evidence of CSM as determined by signs and symptoms including, but not limited to loss of manual dexterity, extremity weakness, sensory abnormalities, quadriparesis, loss of proprioception, and positive Babinski's or Hoffman's sign. Exclusion Criteria: * pregnant * having an MRI incompatible device * having a known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and/or lumbar stenosis, spine tumor or HIV-related myelopathy and having systemic instability or being deemed unable to tolerate standard MRI sequencing.

What they're measuring

Accurate prediction of neurologic outcomes after surgery

Timeframe: 24 months

Trial details

NCT IDNCT03296592

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-03-30

View on ClinicalTrials.gov More Cervical Spondylotic Myelopathy trials