CompletedNot Applicable

Effects of Positive End-expiratory Pressure on Intracranial Pressure in Patients With Severe Traumatic Brain Injury

38 participantsStarted 2016-08-01

Plain-language summary

The impact of PEEP on ICP was dependent on the difference between elevated CVP levels and baseline ICP levels. ICP would increase once elevated CVP through PEEP adjustment exceeds the baseline ICP.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All patients diagnosed with sTBI (GCS≤8) and applied with MV were initially included. Exclusion Criteria: * Brain death * Younger than 18 or older than 80 years * Pregnancy * Hemodynamic instability：for example heart rate \>120 bpm or CPP \<60 mmHg * Bulbous lung or pneumothorax * Myocardial infarction * Refusal of consent

What they're measuring

Effects of positive end-expiratory pressure on intracranial pressure in patients with severe traumatic brain injury

Timeframe: up to 12 months

Trial details

NCT IDNCT03296293

SponsorHongpeng Li

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06-15

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